Cholelithiasis, or gallstone disease, is a common gastrointestinal disorder with significant global health implications. Recent studies have suggested a potential association between Helicobacter pylori (H. pylori) infection and the development of cholelithiasis. This meta-analysis aims to synthesize the latest evidence on the role of H. pylori as a risk factor for cholelithiasis. A comprehensive literature search was conducted, and studies published between 2018 and 2023 were included. The results indicate a significant association between H. pylori infection and an increased risk of cholelithiasis, with potential mechanisms involving chronic inflammation, altered lipid metabolism, and bile composition changes. This analysis underscores the need for further research to elucidate the causal relationship and explore therapeutic implications.

Keywords: cholelithiasis; Helicobacter pylori; global health; Infection; Chronic Inflammation.